Objective: Treatment of uterine fibroma has been changed during recent years by introduction of LH and RH (luteinizing hormone releasing hormone). These medicines, which are active via parenteral administration, have proved remarkably effective and, are devoid of metabolic effects. They do engender some disagreeable adverse reaction, and unfortunately their efficacy is transitory and their cost is high.Materials and Methods: According to traditional treatment which mentioned in Zakhireh Kharazmeshahy (narrated by Jorjany), Exire Azam (), and Avesina Medical Law there are herbal compound (we called F2) which can be used as vaginal suppository has excellent affect on the uterus fibroma.Results: In this study we applied F2 on eight patients suffering uterus fibroma, with the following results. Five (62.5%) patients were cured and did not have any sign of disease during at least four months. The result of treatment in one (12.5%) patient was mild but in two (25%) other patients remained moderate.Conclusion: In patient suffering Uterine Fibroma it is recommended to apply the herbal medicine which is cheaper and cure the disease, instead of LH and RH (luteinizing hormone releasing hormone) which are expensive and have transient effect.